Viewing archived talks in: St Andrews
Speaker: Timothy Noel (Eindhoven)
Innovation in synthetic methodology through use of flow
On: March 13, 2019 From: 14h00 To: 15h00View talk
ScotCHEM Industry Talk - Biology needs organic chemistry; Concept Life Sciences chemistry for ADC, PROTAC, kinase and nucleotide research.
Speaker: Dr Matilda Bingham (Concept Life Sciences)
Concept Life Sciences is a science-led business focused on delivering a comprehensive platform of services of which organic synthesis forms a critical part. Our chemists work in a collaborative way with colleagues in biology, DMPK (distribution, metabolism and pharmacokinetics), bioanalytics and toxicology to design chemistry to apply to novel small molecules, biomolecules, peptide conjugates and hybrid molecules as part of wider research programmes designed to answer critical questions about biological systems. In this talk, we will discuss some of our work in the areas of antibody drug conjugates (ADCs), protein targeting chimaeras (PROTACs), kinase inhibitors and nucleotides.
On: May 2, 2019 From: 14h00 To: 15h00View talk
Speaker: Dr Amanda Jarvis (Edinburgh)
Guiding catalyst selectivity using biological architecture Dr Amanda Jarvis, University of Edinburgh Artificial metalloenzymes aim to combine the benefits of natural enzymes (selectivity, rate enhancement) with the scope of reactions provided by traditional transition metal chemistry (both reactions inspired by nature e.g. oxidations and reactions never s een in nature i.e. Pd cross -coupling reactions). 1 Proteins containing apolar cavities and tunnels have been utilised as scaffolds in which transition metal complexes can be introduced to build up catalysts that provide linear selectivities and improve subs trate turnover through enhancing substrate binding. 2 A number of different methods can be utilised to introduce the metal complex into the protein scaffold, including either introducing reactive amino acids (e.g. cysteineâ€™s) which can subsequently be modi fied with a metal binding ligand, or directly introducing metal binding unnatural amino acids such as bipyridylalanine using amber stop codon suppression methodology. 3 In this talk, I will cover the work I have conducted towards developing artificial metal loenzymes using these methods for a range of synthetic challenges from reactions in water to C -H functionalisation.
On: May 8, 2019 From: 14h00 To: 15h00View talk
Biocatalysis in drug discovery and drug development: Reimagining the manufacture of medicine at Novartis
Speaker: Dr Radka Snajdrova (Novartis)
On: May 15, 2019 From: 14h00 To: 15h00View talk