TBC

Innovation in synthetic methodology through use of flow

Concept Life Sciences is a science-led business focused on delivering a comprehensive platform of services of which organic synthesis forms a critical part. Our chemists work in a collaborative way with colleagues in biology, DMPK (distribution, metabolism and pharmacokinetics), bioanalytics and toxicology to design chemistry to apply to novel small molecules, biomolecules, peptide conjugates and hybrid molecules as part of wider research programmes designed to answer critical questions about biological systems. In this talk, we will discuss some of our work in the areas of antibody drug conjugates (ADCs), protein targeting chimaeras (PROTACs), kinase inhibitors and nucleotides. 

Guiding catalyst selectivity using biological architecture Dr Amanda Jarvis, University of Edinburgh Artificial metalloenzymes aim to combine the benefits of natural enzymes (selectivity, rate enhancement) with the scope of reactions provided by traditional transition metal chemistry (both reactions inspired by nature e.g. oxidations and reactions never s een in nature i.e. Pd cross -coupling reactions). 1 Proteins containing apolar cavities and tunnels have been utilised as scaffolds in which transition metal complexes can be introduced to build up catalysts that provide linear selectivities and improve subs trate turnover through enhancing substrate binding. 2 A number of different methods can be utilised to introduce the metal complex into the protein scaffold, including either introducing reactive amino acids (e.g. cysteine’s) which can subsequently be modi fied with a metal binding ligand, or directly introducing metal binding unnatural amino acids such as bipyridylalanine using amber stop codon suppression methodology. 3 In this talk, I will cover the work I have conducted towards developing artificial metal loenzymes using these methods for a range of synthetic challenges from reactions in water to C -H functionalisation.

https://talks.st-andrews.ac.uk/index.php?talks/view/nil/2/nil/